abstract：:Calcineurin is a serine/threonine protein phosphatase that regulates neurotransmission, neuronal structure and plasticity, and neuronal excitability in mood disorders, including depression. Increasing evidence has suggested that calcineurin is involved in the regulation of depressive-like behavior. However, little is ...

journal_title：Journal of neurochemistry

authors： Zhu WL,Shi HS,Wang SJ,Wu P,Ding ZB,Lu L

更新日期：2011-06-01 00:00:00

abstract：:Microglia are the main players of the brain immune response. They act as active sensors that rapidly respond to injurious insults by shifting into different activated states. Elevated levels of unconjugated bilirubin (UCB) induce cell death, immunostimulation and oxidative stress in both neurons and astrocytes. We rec...

journal_title：Journal of neurochemistry

authors： Silva SL,Osório C,Vaz AR,Barateiro A,Falcão AS,Silva RF,Brites D

更新日期：2011-05-01 00:00:00

abstract：:Neural stem cells (NSCs) are self-renewing multipotent cells that undergo symmetric and asymmetric cell division during development of the nervous system. The behavior of NSCs is tightly regulated by intrinsic processes such as transcriptional and post-transcriptional control, as well as the stem cell niche factors th...

journal_title：Journal of neurochemistry

authors： Gan HT,Tham M,Hariharan S,Ramasamy S,Yu YH,Ahmed S

更新日期：2011-05-01 00:00:00

abstract：:Stem cell-based approaches provide hope as a potential therapy for neurodegenerative diseases and stroke. One of the major scientific hurdles for stem cell therapy is the poor survival rate of the newly formed or transplanted neural stem cells. In this study, we found that low-dose treatment with the Heat shock protei...

journal_title：Journal of neurochemistry

authors： Wang G,Krishnamurthy K,Tangpisuthipongsa D

更新日期：2011-05-01 00:00:00

abstract：:Rat hippocampal glutamatergic terminals possess NMDA autoreceptors whose activation by low micromolar NMDA elicits glutamate exocytosis in the presence of physiological Mg(2+) (1.2 mM), the release of glutamate being significantly reduced when compared to that in Mg(2+)-free condition. Both glutamate and glycine were ...

journal_title：Journal of neurochemistry

authors： Musante V,Summa M,Cunha RA,Raiteri M,Pittaluga A

更新日期：2011-05-01 00:00:00

abstract：:Action mechanism of lipopolysaccharide (LPS), interleukin-1β (IL-1β), and lysophosphatidic acid (LPA) to regulate motility, an important process of astrogliosis, was investigated in rat astrocytes. While LPA exerted no significant effect on the cell migration, the prior treatment of the cells with LPS or IL-1β resulte...

journal_title：Journal of neurochemistry

authors： Sato K,Horiuchi Y,Jin Y,Malchinkhuu E,Komachi M,Kondo T,Okajima F

更新日期：2011-04-01 00:00:00

abstract：:Monoamine action in the dorsal striatum and nucleus accumbens plays essential roles in striatal physiology. Although research often focuses on dopamine and its receptors, norepinephrine (NE) and adrenergic receptors are also crucial in regulating striatal function. While noradrenergic neurotransmission has been identi...

journal_title：Journal of neurochemistry

authors： Meitzen J,Luoma JI,Stern CM,Mermelstein PG

更新日期：2011-03-01 00:00:00

abstract：:The two proteins reggie-1/flotillin-2 and reggie-2/flotillin-1 form microdomains at the plasma membrane and at intracellular compartments where src tyrosine kinases associate with them. Specific GPI-anchored proteins, in particular prion protein and Thy-1, co-cluster with reggie microdomains at the plasma membrane and...

journal_title：Journal of neurochemistry

authors： Stuermer CA

更新日期：2011-03-01 00:00:00

abstract：:G-protein coupled receptors may mediate their effects on neuronal growth and differentiation through activation of extracellular signal-regulated kinases 1/2 (ERK1/2), often elicited by transactivation of growth factor receptor tyrosine kinases. This elaborate signaling process includes inducible formation and traffic...

journal_title：Journal of neurochemistry

authors： Asimaki O,Leondaritis G,Lois G,Sakellaridis N,Mangoura D

更新日期：2011-03-01 00:00:00

abstract：:The Cys-loop receptor family consists of nicotinic acetylcholine receptors (nAChR), glycine receptor, GABA-A and some other receptors. They fulfill a plethora of functions, whereas their malfunctioning is associated with many diseases. All three domains - extracellular ligand-binding, membrane and cytoplasmic - of the...

journal_title：Journal of neurochemistry

authors： Tsetlin V,Kuzmin D,Kasheverov I

更新日期：2011-03-01 00:00:00

abstract：:Dendritic trafficking and translation of brain-derived neurotrophic factor (BDNF) transcripts play a key role in mediating synaptic plasticity. Recently, we demonstrated that siRNA-mediated knockdown of translin, an RNA-binding protein, impairs KCl-induced dendritic trafficking of BDNF mRNA in cultured hippocampal neu...

journal_title：Journal of neurochemistry

authors： Wu YC,Williamson R,Li Z,Vicario A,Xu J,Kasai M,Chern Y,Tongiorgi E,Baraban JM

更新日期：2011-03-01 00:00:00

abstract：:Juvenile neuronal ceroid lipofuscinosis (Batten disease) is a neurodegenerative disorder caused by mutation in CLN3. Defective autophagy and concomitant accumulation of autofluorescence enriched with mitochondrial ATP synthase subunit c were previously discovered in Cln3 mutant knock-in mice. In this study, we show th...

journal_title：Journal of neurochemistry

authors： Chang JW,Choi H,Cotman SL,Jung YK

更新日期：2011-02-01 00:00:00

abstract：:Astrogliosis occurs after brain ischemia, and excessive astrogliosis can devastate the neuronal recovery. Previous reports show that galectin-1 (Gal-1) regulates proliferation of several cell types and plays an important role after nervous system injuries. Here, we found that expression of Gal-1 was remarkably up-regu...

journal_title：Journal of neurochemistry

authors： Qu WS,Wang YH,Ma JF,Tian DS,Zhang Q,Pan DJ,Yu ZY,Xie MJ,Wang JP,Wang W

更新日期：2011-01-01 00:00:00

abstract：:Both hypercortisolemia and hippocampal damage are features found in patients diagnosed of Alzheimer's disease (AD) and epidemiological evidence supports a role for stress as a risk factor for AD. It is known that immobilization stress is followed by accumulation of oxidative/nitrosative mediators in brain after the re...

journal_title：Journal of neurochemistry

authors： Perez Nievas BG,Hammerschmidt T,Kummer MP,Terwel D,Leza JC,Heneka MT

更新日期：2011-01-01 00:00:00

abstract：:D-serine is a co-agonist of NMDA receptor (NMDAR) and plays important roles in synaptic plasticity mechanisms. Serine racemase (SR) is a brain-enriched enzyme that converts L-serine to D-serine. SR interacts with the protein interacting with C-kinase 1 (PICK1), which is known to direct protein kinase C (PKC) to its ta...

journal_title：Journal of neurochemistry

authors： Vargas-Lopes C,Madeira C,Kahn SA,Albino do Couto I,Bado P,Houzel JC,De Miranda J,de Freitas MS,Ferreira ST,Panizzutti R

更新日期：2011-01-01 00:00:00

abstract：:Microglia are known to be a primary inflammatory cell type in the brain. However, microglial inflammatory responses are attenuated in the injured brain compared to those in cultured pure microglia. In the present study, we found that astrocytes challenged by oxygen-glucose deprivation (OGD) or H(2) O(2) released solub...

journal_title：Journal of neurochemistry

authors： Kim JH,Min KJ,Seol W,Jou I,Joe EH

更新日期：2010-12-01 00:00:00

abstract：:Myelination of peripheral nerves by Schwann cells depends upon a gene regulatory network controlled by early growth response Egr2/Krox20, which is specifically required for Schwann cells to initiate and maintain myelination. To elucidate the mechanism by which Egr2 regulates gene expression during myelination, we have...

journal_title：Journal of neurochemistry

authors： Jang SW,Srinivasan R,Jones EA,Sun G,Keles S,Krueger C,Chang LW,Nagarajan R,Svaren J

更新日期：2010-12-01 00:00:00

abstract：:Alcohol abuse leads to tolerance, dependence, and memory impairments that involve excitatory glutamatergic NMDA synaptic transmission. The NMDA receptor (NMDAR) is known to undergo activity-dependent adaptive functional changes. Since we observed that acute ethanol inhibition of the NMDAR was regulated by protein tyro...

journal_title：Journal of neurochemistry

authors： Wu PH,Coultrap S,Browning MD,Proctor WR

更新日期：2010-12-01 00:00:00

abstract：:Glutamate in the prefrontal cortex (PFC) plays a significant role in several mental illnesses, including schizophrenia, addiction and anxiety. Previous studies on PFC glutamate-mediated function have used techniques that raise questions on the neuronal versus astrocytic origin of glutamate. The present studies used en...

journal_title：Journal of neurochemistry

authors： Hascup ER,Hascup KN,Stephens M,Pomerleau F,Huettl P,Gratton A,Gerhardt GA

更新日期：2010-12-01 00:00:00

abstract：:Epoxyeicosatrienoic acids (EETs) are bioactive eicosanoids produced from arachidonic acid by cytochrome P450 epoxygenases. We previously described the expression of cytochrome P450-2J epoxygenase in rat trigeminal ganglion neurons and that EETs signaling is involved in cerebrovascular dilation resulting from perivascu...

journal_title：Journal of neurochemistry

authors： Iliff JJ,Fairbanks SL,Balkowiec A,Alkayed NJ

更新日期：2010-12-01 00:00:00

abstract：:Ammonium (NH(4) (+) ) is required to maintain pathways involved in shuttling metabolic precursors between astrocytes and neurones. Under hyperammonaemic conditions, increases in the cellular influx of NH(4) (+) , and accompanying changes in ion concentrations, may contribute to disruptions in metabolism and neurotrans...

journal_title：Journal of neurochemistry

authors： Kelly T,Rose CR

更新日期：2010-12-01 00:00:00

abstract：:Mitochondrial dysfunction and oxidative stress are known to occur following acute seizure activity but their contribution during epileptogenesis is largely unknown. The goal of this study was to determine the extent of mitochondrial oxidative stress, changes to redox status, and mitochondrial DNA (mtDNA) damage during...

journal_title：Journal of neurochemistry

authors： Waldbaum S,Liang LP,Patel M

更新日期：2010-12-01 00:00:00

abstract：:The roles of two subtypes of corticotrophin-releasing factor (CRF) receptor in corticostriatal synaptic plasticity under cocaine withdrawal condition were examined in this study. Neither the resting membrane potential and input resistance of striatal neurons nor the long-term potentiation (LTP) of corticostriatal slic...

journal_title：Journal of neurochemistry

authors： Guan X,Wang L,Chen CL,Guan Y,Li S

更新日期：2010-11-01 00:00:00

abstract：:Temporal carbohydrate expression patterns at cell surfaces are thought to be of crucial regulatory significance during developmental processes. Hitherto, however, data on individual membrane proteins undergoing development-associated changes in glycosylation are sparsely. Here, we show that the two natriuretic peptide...

journal_title：Journal of neurochemistry

authors： Müller D,Hildebrand M,Lübberstedt J,Kuhn M,Middendorff R

更新日期：2010-11-01 00:00:00

abstract：:Null mutations in progranulin (GRN) are associated with frontotemporal lobar degeneration characterized by intraneuronal accumulation of TAR DNA-binding protein-43 (TDP-43). However, the mechanism by which GRN deficiency leads to neurodegeneration remains largely unknown. In primary cortical neurons derived from Grn k...

journal_title：Journal of neurochemistry

authors： Kleinberger G,Wils H,Ponsaerts P,Joris G,Timmermans JP,Van Broeckhoven C,Kumar-Singh S

更新日期：2010-11-01 00:00:00

abstract：:Apolipoprotein E (apoE) plays a crucial role in lipid transport in circulation and the brain. The apoE4 isoform is a major risk factor for Alzheimer's disease (AD). ApoE4 is more susceptible to proteolysis than other apoE isoforms and apoE4 fragments have been found in brains of AD patients. These apoE4 fragments have...

journal_title：Journal of neurochemistry

authors： Dafnis I,Stratikos E,Tzinia A,Tsilibary EC,Zannis VI,Chroni A

更新日期：2010-11-01 00:00:00

abstract：:Neuropeptide S (NPS) is known to produce anxiolytic-like effects and facilitate extinction of conditioned fear. Catecholaminergic neurotransmission in the medial prefrontal cortex (mPFC) has been suggested to be crucially involved in these brain functions. In the current study, we investigated the effect of NPS on the...

journal_title：Journal of neurochemistry

authors： Si W,Aluisio L,Okamura N,Clark SD,Fraser I,Sutton SW,Bonaventure P,Reinscheid RK

更新日期：2010-10-01 00:00:00

abstract：:Protracted opiate withdrawal can extend for months of disrupted hormonal circadian rhythms. We examined rodent behaviors and these circadian disturbances in hormone and peptide levels as well as brain clock gene expression during 60 days of protracted withdrawal. Our behavioral tests included open field, elevated plus...

journal_title：Journal of neurochemistry

authors： Li SX,Liu LJ,Jiang WG,Sun LL,Zhou SJ,Le Foll B,Zhang XY,Kosten TR,Lu L

更新日期：2010-10-01 00:00:00

abstract：:The extracellular matrix (ECM) is important for both structural integrity and functions of the brain. Matrix metalloproteinases (MMPs) play major roles in ECM-remodeling under both physiological and pathological conditions. Reversion-inducing cysteine-rich protein with Kazal motifs (Reck) is a membrane-anchored MMP-re...

journal_title：Journal of neurochemistry

authors： Wang H,Imamura Y,Ishibashi R,Chandana EP,Yamamoto M,Noda M

更新日期：2010-10-01 00:00:00

abstract：:Prolonged seizures activate members of the Bcl-2 homology domain 3-only sub-group of the Bcl-2 protein family, which are essential for initiation of apoptosis signaling. Bid is a potent pro-apoptotic Bcl-2 homology domain 3-only protein, which upon proteolytic activation translocates to mitochondria to promote activat...

journal_title：Journal of neurochemistry

authors： Engel T,Caballero-Caballero A,Schindler CK,Plesnila N,Strasser A,Prehn JH,Henshall DC

更新日期：2010-10-01 00:00:00

abstract：:In the present study, by means of genetic, biochemical, morphological, and electrophysiological approaches, the role of large-conductance voltage- and Ca(2+)-dependent K(+) channels (BK channels) in the release of excitatory and non-excitatory neurotransmitters at hippocampal and non-hippocampal sites has been investi...

journal_title：Journal of neurochemistry

authors： Martire M,Barrese V,D'Amico M,Iannotti FA,Pizzarelli R,Samengo I,Viggiano D,Ruth P,Cherubini E,Taglialatela M

更新日期：2010-10-01 00:00:00

abstract：:The decrease of pyruvate and ketoglutarate dehydrogenase complex activities is the main cause of energy and acetyl-CoA deficits in thiamine deficiency-evoked cholinergic encephalopathies. However, disturbances in pathways of acetyl-CoA metabolism leading to appearance of cholinergic deficits remain unknown. Therefore,...

journal_title：Journal of neurochemistry

authors： Jankowska-Kulawy A,Bielarczyk H,Pawełczyk T,Wróblewska M,Szutowicz A

更新日期：2010-10-01 00:00:00

abstract：:Substances that mimic the actions of causative gene products of familial Parkinson's disease (PD) are candidate as causative agents of idiopathic PD. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, is present at three times higher levels in CSF of PD patients than in CSF of control subjects...

journal_title：Journal of neurochemistry

authors： Kohta R,Kotake Y,Hosoya T,Hiramatsu T,Otsubo Y,Koyama H,Hirokane Y,Yokoyama Y,Ikeshoji H,Oofusa K,Suzuki M,Ohta S

更新日期：2010-09-01 00:00:00

abstract：:Rho kinase (ROCK) may play an important role in regulating biological events of cells, including proliferation, differentiation and survival/death. Blockade of ROCK promotes axonal regeneration and neuron survival in vivo and in vitro, thereby exhibiting potential clinical applications in spinal cord damage and stroke...

journal_title：Journal of neurochemistry

authors： Ding J,Li QY,Wang X,Sun CH,Lu CZ,Xiao BG

更新日期：2010-09-01 00:00:00

abstract：:A diverse group of neurodegenerative diseases - including progressive supranuclear palsy (PSP), corticobasal degeneration and Alzheimer's disease among others, collectively referred to as tauopathies - are characterized by progressive, age-dependent intracellular formations of misfolded protein aggregates that play ke...

journal_title：Journal of neurochemistry

authors： Pasinetti GM,Ksiezak-Reding H,Santa-Maria I,Wang J,Ho L

更新日期：2010-09-01 00:00:00

abstract：:The cochleo-vestibular ganglion contains neural crest-derived glial cells and sensory neurons that are derived from the neurogenic otic placode. Little is known about the molecular mechanisms that regulate the tightly orchestrated development of this structure. Here, we report that Sox10, a high-mobility group DNA-bin...

journal_title：Journal of neurochemistry

authors： Breuskin I,Bodson M,Thelen N,Thiry M,Borgs L,Nguyen L,Stolt C,Wegner M,Lefebvre PP,Malgrange B

更新日期：2010-09-01 00:00:00

abstract：:Autism is a behaviorally defined neurodevelopmental disorder and among its symptoms are disturbances in face and emotional processing. Emerging evidence demonstrates abnormalities in the GABAergic (gamma-aminobutyric acid) system in autism, which likely contributes to these deficits. GABA(B) receptors play an importan...

journal_title：Journal of neurochemistry

authors： Oblak AL,Gibbs TT,Blatt GJ

更新日期：2010-09-01 00:00:00

abstract：:Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. Yet the specific effects of HFD consumption on brain aging are poorly understood. In the present study 20-month old male C57Bl/6 mice were fed either 'western diet' (41% fat), very high fat lard diet (60% fat), or correspo...

journal_title：Journal of neurochemistry

authors： Morrison CD,Pistell PJ,Ingram DK,Johnson WD,Liu Y,Fernandez-Kim SO,White CL,Purpera MN,Uranga RM,Bruce-Keller AJ,Keller JN

更新日期：2010-09-01 00:00:00

abstract：:Neuroprotection is one of the prominent functions of the interleukin (IL)-6-type cytokine family, for which the underlying mechanism(s) are not fully understood. We have previously shown that neuroprotection and neuromodulation mediated by IL-6 require neuronal adenosine A(1) receptor (A(1) R) function. We now have in...

journal_title：Journal of neurochemistry

authors： Moidunny S,Dias RB,Wesseling E,Sekino Y,Boddeke HW,Sebastião AM,Biber K

更新日期：2010-09-01 00:00:00

abstract：:Adrenomedullary chromaffin cells represent an excellent model to study the molecular events linked to exocytosis, because they use the same type of SNAREs for vesicle docking and fusion as neurons. In these cells, both in the intact tissue and in isolated cells in culture, syntaxin-1 and SNAP-25 are present in the pla...

journal_title：Journal of neurochemistry

authors： López-Font I,Torregrosa-Hetland CJ,Villanueva J,Gutiérrez LM

更新日期：2010-09-01 00:00:00